The family run business of Main Street Pharmacy has a long standing history with the beautiful town of Thessalon. In 1994, James and Donna Orlando relocated their family to Thessalon to purchase Main Street Pharmacy, which they independently owned and operated for over 25 years. In 2021, the torch was passed to their children, Jamie and Marc Orlando, maintaining the family run business. We are a proud employer of Thessalonians, supporter of local sports teams and organizations, and active members of our community. Living in Thessalon for nearly 30 years, our family takes pride in caring for your family.